2000-2002

In 2000, The Corrs returned to mainstream success with In Blue. Unlike their previous albums, In Blue broke away from folk rock to become pop music. This move attracted criticism from many critics; one Entertainment Weekly critic called it a a disheartening example of musical ethnic cleansing. Despite this, In Blue hit #1 in its first sales week in the U.K., Ireland, Australia, Germany, Switzerland, and Austria and debuted at #2 in France and Norway. It climbed to the top position during its second week in Sweden and Spain.

The Corrs worked with Alejandro Sanz on In Blue, recording Una Noche (One Night) as a duet between Sanz and Andrea; Sanz also played Andrea's love interest in the music video. In return, The Corrs performed Me Ir? (The Hardest Day) with him on his album, El Alma Al Aire. They also collaborated with Robert Lange to produce a mainstream hit single, Breathless. Breathless reached #34 in the Billboard Hot 100,, #7 in Australia, #3 in Ireland and New Zealand, and #1 in the United Kingdom. The album went straight to #1 in the Irish album charts, and has the third highest sales for week of release in Ireland in the history of the charts, behind U2’s The Best of 1980-1990 and Oasis' Be Here Now. In sales, In Blue reached platinum in the United States, double platinum in the United Kingdom, and quadruple platinum in Australia.

During the production of the album, the Corrs' mother, Jean, died while waiting for a lung transplant in Freeman Hospital, Newcastle. She was laid to rest at St. Patrick's cemetery in Dundalk, and many Bono, Larry Mullen, Brian Kennedy and Paul Brady were among the funeral's attendees. No More Cry, written by Andrea and Caroline Corr for the album, was dedicated to their father to get over his grief.

In 2001, The Corrs released their first compilation album, Best of The Corrs. The album featured previously-released songs and new tracks, such as the single Would You Be Happier, Make You Mine and Lifting Me. The album did not chart high in Ireland but it reached platinum status in Australia.

The Corrs composed a duet, Canto Alla Vita, with Josh Groban for his eponymous debut album. When the band returned to Ireland, they hosted a live concert at Ardmore Studios, Co. Wicklow, Ireland, where they had previously performed for the MTV's Unplugged series. Guest performers included Bono from U2 and Ron Wood from the Rolling Stones. During the concert, Bono joined Andrea Corr for a duet of Nancy Sinatra's Summer Wine and a performance of Ryan Adams' When the Stars Go Blue. Ron Wood joined the band onstage to play guitar on their version of Jimi Hendrix's Little Wing and the Rolling Stones' Ruby Tuesday. These live performances were recorded and put into a live album: VH1 Presents: The Corrs, Live in Dublin, which was only released in the US